Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element

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Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element†

The interaction between human immunodeficiency virus type 1 (HIV-1) and RNA silencing pathways is complex and multifaceted. Essential for efficient viral transcription and supporting Tat-mediated transactivation of viral gene expression, the trans-activation responsive (TAR) element is a structured RNA located at the 5' end of all transcripts derived from HIV-1. Here, we report that this elemen...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2008

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/gkn076